Farmakológia

Ošetrovateľské techniky a zručnosti

Pharmacology of autonomic nervous system

1. Which of the following receptors belong to the group of ionotropic receptors?

a) nicotinic N_N receptor

b) insulin receptors

c) muscarinic M₃ receptor

d) receptor tyrosine kinases

2. Choose a correct statement. α₁ adrenoceptors are typically present in:

a) m. sphincter pupillae
b) m. dilatator pupillae
c) m. ciliaris
d) m. detrusor

3. Choose correct statement. Antagonists of M₁ receptors:

a) decrease the activity of PLC – phospholipase C
b) decrease the activity of AC - adenyl cyclase
c) increase the activity of PLC – phospholipase C
d) increase the activity of AC- adenyl cyclase

4. Choose a correct statement. G_qprotein leads to:

a) ↓ activity of AC, ↓ cAMP, ↑ activity of K⁺ channels
b) ↑ activity of phospholipase C, ↑ IP₃ , ↑ DAG, ↑ Ca²⁺
c) ↑ activity of K⁺ channels, ↓ Ca²⁺
d) ↑ activity of AC, ↑ cAMP

5. Choose a correct combination of drug and its clinical use:

a) oxybutynin - asthma
b) labetalol – hypertensive crisis
c) phenoxybenzamine – erectile dysfunction
d) butylscopolamine – opthalmologic examination of retina

6. Which of the following drugs should be used in the therapy of a patient after acute myocardial infarction complicated by severe sinus bradycardia (40 beats/min)?

a) acetylcholine
b) arecoline
c) atropine
d) apraclonidine

7. Which drug should be used to treat myasthenia gravis?

a) neostigmine
b) atropine
c) mirabegron
d) varenicline

8. Choose an appropriate management of symptomatic β-adrenergic blocker overdose:

a) atropine
b) atropine + pralidoxime
c) physostigmine
d) glucagon + dobutamine

9. Choose a correct completion of this statement: Short biological half-life is a typical pharmacokinetic feature of:

a) esmolol
b) nadolol
c) bisoprolol
d) carvedilol

10. Is following statement correct? Orthostatic hypotension can be caused by selective α₁ receptor blockers.

a) Yes
b) No

11. Choose a correct completion of the following statement: Short acting agonists of β₂ receptors (SABA) (4p):

a) sa are used as relievers to suppress acute bronchoconstriction

b) should be combined with ipratropium in one inhalator system as so called controllers

for long-term anti-inflammatory therapy

c) are used for COPD treatment only

d)are never combined with parasympatholytics due to severe adverse effects

12. Hemodynamic effect of dopamine is dose-dependent.
The dose level of dopamine at which a renal perfusion mediated by peripheral D₁ receptors will be improved only is:

a) 2 – 5 μg/kg/min
b) 5-10 μg/kg/min
c) 10-30 μg/kg/min
d) more than 30 μg/kg/min

13. Choose a correct completion of the statement: β blockers due to intrinsic sympathomimetic activity have:

a) higher risk of metabolic side effects
b) lower incidence of bronchoconstriction
c) antagonistic effects on alpha adrenoreceptors
d) aj CNS adverse effects

14. Propranolol is a competitive antagonist of β adrenoreceptors. It means that (choose a correct completion of the statement):

a) it has intrinsic activity but no affinity for β adrenoreceptors
b) sa it binds to a site different to that of an agonist, e.g. epinephrine
c) it has affinity but no activity for β adrenoreceptors
d) sa it binds on ₂ receptors, but have opposite effects than agonist of β adrenoreceptors

15. Which of the following drugs is not used for the therapy of glaucoma?

a) pilocaprine
b) atropine
c) timolol
d) betaxolol

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