Farmakológia

Ošetrovateľské techniky a zručnosti

Pharmacology of hormonal system

1. Choose a correct completing of this statement: The mechanism of insulin action is associated with:

a) receptors located in the nucleus

b) G-protein receptors

c) tyrosine kinase receptor complex

d) second messengers

2. Choose a correct completing of this statement: The adverse effect of insulin can be:

a) hyperglycemia
b) lipodystrophy
c) GIT disturbances
d) hematologic toxicity

3. Choose a cortrect statement about biguanides. Biguanides:

a) are the only oral antidiabetics that can be used in pregnancy
b) metformin is a main representative of biguanides
c) can cause weight gain
d) to have always combine with insulin

4. Choose a correct statement about the mechanism of action of sulfonylureas.

a) They inhibit K_ATP+ channels and increase an insulin release from B-cells
b) . Their mechanism of action does not depend on functioning pancreatic B-cells
c) They inhibit Na⁺ channels and increase an insulin release from B-cells
d) Sulfonylureas are insulin sensitisers

5. Choose a correct information about glargine. Glargine is:

a) an insulin sensitizer
b) a prandial insulin
c) a GLP-1 analog
d) a long-lasting insulin analog

6. Choose a correct statement about glucocorticoids. Glucocorticosterids:

a) stimulate production of proinflammatory cytokines
b) decrease production of proinflammatory cytokines
c) do not influence cytokines production
d) affect only antiinflammatory cytokines

7. Which of the following drugs is used in the asthma treatment as an inhalatory steroid?

a) fludrocortisone
b) momethasone
c) fluticasone
d) halcinonide

8. Which of the following steroids has prediminantly mineralcorticoid effect?

a) hydrocorticone
b) desoxycorticosterone
c) budenoside
d) bethametasone

9. Choose a typical adverse effect of glucocorticoids:

a) hypotension
b) osteoporosis
c) hypoglycemia
d) stomach hypoacidity

10. Choose a correct statement. In longer treatment with high dose of GCs:

a) is necessery to decrease the dose weekly by half, later reduce every 3-7 days
b) is necessary to replace long-acting agents with short-acting
c) is necessary to reduce number of doses per day
d) cessation of therapy should be abrupt

11. Choose a correct statement about tamoxifene. Tamoxifene:

a) is antiprogestin

b) is SERM with agonistic effect in the bone and uterus, antagonistic effect in breast

c) is aromatase inhibitor

d) inhibits the estrogen synthesis

12. Which of the following drugs acts as an antiandrogen?

a) flutamide
b) nandrolone
c) mifepristone
d) clomiphene

13. Modern combinations of contraceptives contains ethinyl estradiol at a dose of:

a) 50 µg
b) 100 µg
c) 20 µg
d) more than these doses

14. Choose a correct statement about adverse effect of anabolic ateroids. Anabolic steroids can:

a) decrease the blood pressure
b) increase the sexual functions
c) increase the risk of heart enlargement and liver damage
d) cause sedation

15. Choose a correct combination of drug and its pharmacoogical group:

a) raloxifene - glucocorticoid
b) finasterid - antiandrogen
c) levonorgestrel - estrogen
d) nateglinid – insulin analog

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