Prostate cancer
A 60-years-old man is found to have prostate lump and an elevated prostate-specific antigen (PSA) blood test. Magnetic resonance imaging suggests several enlarged lymph nodes in the lower abdomen, and an X-ray reveals 2 radiolucent lesions in the bony pelvis.
Questions and tasks
1. What kind of disease is the most probable diagnose of this patient?
2. Describe the role of testosterone, including its production and regulation of its synthesis.
3. This patient is likely to be treated with which of the following drugs?
a) anastrozol
b) desogestrel
c) flutamide
d) methyltestoterone
e) oxandrolone
4. Finasteride has efficacy in the prevention of male-pattern baldness by virtue of its ability to do which of the following?
a) competitive antagonize androgen receptors
b) decrease the release of gonadotropins
c) increase the serum concentration of sex hormone-binding globulin
d) inhibit synthesis of testosterone
e) reduce the production of dihydrotestosterone
5. What are other options of the treatment for patients with prostate cancer and BPH?
6. Men who use large doses of anabolic streroids are at increased risk of which of the following?
a) anemia
b) cholestatic jaundice and elevation of aspartate transaminase levels in the blood
c) hirsutism
d) hyperprolactinemia
e) testicular enlargement
7. Describe other adverse effects of anabolic hormones and give examples of the major representatives.