Malaria
A traveler in a geographical region where chloroquine-resistant P. falciparum is endemic used a drug for profylaxis but nevertheless developed a severe attack of P. vivax malaria
Questions and tasks
1. The drug taken for chemoprophylaxis was probably:
a) atovaquone
b) mefloquine
c) metronidazole
d) proguanil
e) quinine
2. Which drug should be used for oral treatment of the acute attack of P. vivax malaria, but does not eradicate exoerythrocytic forms of the parasite?
a) chloroquine
b) mefloquine
c) primaquine
d) pyrimethamine-sulfadoxine
e) quinidine
3. Which drug should be given later to eradicate schizonts and latent hypnozoites in the patient’s liver?
a) artemisinin
b) doxycyclin
c) primaquine
d) quinine
e) sulfadoxine
4. Plasmodial resistance to chloroquine is due to:
a) change in receptor structure
b) decreased accumulation of the drug in the food vacuole
c) increase in the activity of DNA repair mechanisms
d) induction of drug-inactivating enzymes
e) increased synthesis of dihydrofolate reductase
5. Which statement about antiprotozoal drugs is accurate?
a) chloroquine is an inhibitor of plasmodial dihydrofolate reductase
b) mefloquine destroys secondary exoerythrocytic schizonts
c) primaquine is a blood schizontocide and does not affect secondary tissue schizonts
d) proguanil complexes with double-stranded DNA-blocking replication
e) trimethoprim-sulfamethoxazole is the drug of choice for P. jirovecii pneumonia